Add to it semaglutide slowing down food digestion, and it makes for a crazy combination
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The main targets in these models are thyroid follicular cells, immune cells (particularly T lymphocytes), and the autoantibodies that bind to thyroid antigens
Efficacy and Safety of OnceWeekly Semaglutide Versus Once-Daily Insulin Glargine as Add On to Metformin (with or without Sulfonylureas) in Insulin-Naive Patients with Type 2 Diabetes (SUSTAIN 4): A Randomised, OpenLabel, Parallel-Group, Multicentre, Multinational, Phase 3a Trial
Triple agonists combining GLP 1, GIP and glucagon receptor activity represent another frontier with early data suggesting these may produce even greater weight loss and metabolic improvements